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KMID : 0352519840210010237
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Korea Univercity Medical Journal
1984 Volume.21 No. 1 p.237 ~ p.248
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Experimental Comparison Study between Truncal Vagotomy with Pyloroplasty, Selective Vagotomy with Pyloroplasty and Parietal cell Vagotomy on Gastric Secretion after Histamine Stimulation
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Abstract
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The goal of the therapy for peptic disease is to reduce the acid-pepsin secretion in the stomach and the recurrence rate, and the parietal cell vagotomy is believed to be a suitable operation for this purpose.
The purpose of this study is to report on the response of the gastric secretion after variable vagotomy procedures and to compare the response rate with the administration of histamine in each vagotomy procedures.
The author carried out an experimental study on the gastric secretory response to histamine in total 23 mongrel dogs, 8 control group (gastrostomy), 5 truncal vagotomy with pyloroplasty
group; 5 selective vagotomy with pyloroplasty group and 5 parietal cell vagotomy group.
i
Gastric juice analysis was carried out 3 times on a monthly with the administration of
histamine.
The result are as follows:
1. In group of truncal vagotomy with pyloroplasty, the mean value of free acidity after 1 month, 2 month and 3 month of operation decreased by 70.4io 47.1o and 83.10 respectively in comparison with control group, and mean value of total acidity decreased by 32.10, 24% and 53.1% respectively. The mean value of histamine-responded free acidity after 1 month, 2 month and 3 month of operation decreased by 24%, 43.7% and 48.3% respectively in comparison with control group and mean value of total acidity decreased by 9.40, 21.2% and 38.8% respectively.
2. In group of selective vagotomy with pyloroplasty, the mean value of free acidity after 1 month, 2 montg and 3 month of operation decreased by 18.5%, 41.3% and 25.951/6
respectively, in comparison with control group. The mean value of histamine-responded free _acidity after 1 month, 2 month and 3 month of operation decreased by 27. 1%, 45.4% and 46.5% respectvely, in comparison with control group and mean value of total acidity decreased by 24. 0%, 18.7% and 8.4% respectively.
3. In group of parietal cell vagotomy, the mean value of free acidity after 1 month, 2 month and 3 month of operation decreased by 40. %, r´0.4% and 57.7o respectively, in comparison with control group and mean value of total acidity decreased by 24.0%, 18.7% and S..1% respectively. Then mean value of histamine-responded free acidity after I month, 2 month and 3 month of operation decreased by 33. 7%, 25.1% and 63.8% respectively, in comparison with control group and mean vahie of total acidity decreased by 24.9%, 21.8% and 28.8% respectively.
4. In summary, average reduction rates of free acidity in truncal vagotomy Nvith pyloroplasty, selective vagotomy with pyloroplasty and parietal cell vagotomy were 66. 7%, 29. 2% and 56.3% respectively, and average reduction rates of total acidity, 36.40, +10. 1% and 28.4% respectively. Average reduction rates of histamine-responded free aciditywere 28.7%, 39. 5% and 40. 9% respectively, and histamine-responded total acidity, 23. 1%, 17% and 25.2% respectively.
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